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ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen
Affiliation:1. Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Kyoto 606-8501, Japan;2. Shenzhen University School of Medicine, Shenzhen, Guangdong 518060, China;3. Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;4. RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;5. IFOM-the FIRC Institute of Molecular Oncology, Milan, Italy;6. Department of Medical Systems Genomics, Graduate School of Medicine, Kyoto University, Kyoto, Japan;7. Institute for Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan;8. Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan;9. Department of Urology, Graduate School of Medicine, Kyoto University, 54 Shougoin Kawahara-cho, Kyoto 606-8507, Japan;10. Breast Cancer Unit, Kyoto University Hospital, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan;11. Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan;12. Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA;13. Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Abstract:
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  • Keywords:ataxia-telangiectasia (ATM)  DNA double-strand break repair  enhancer  estradiol  topoisomerase II  c-MYC  breast cancer  CP: Cell biology  CP: Cancer
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