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The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region
Affiliation:1. Department of Gynecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;2. Department of Medical Genetics, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China;3. Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China;4. Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China;5. Department of Microbiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China;6. Hubei Provincial Key Laboratory of Allergy and Immunology, Wuhan 430071, China
Abstract:
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  • Keywords:tumour-suppressor protein OTUD1  Akt signaling pathway  targeted therapies  CP: Molecular biology  CP: Cancer
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