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Mutational fitness landscape of human influenza H3N2 neuraminidase
Affiliation:1. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA;2. Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA;3. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA;4. HeliXon Limited, Beijing 100084, China;5. Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA;6. Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Abstract:
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  • Keywords:influenza  deep mutational scanning  neuraminidase  protein structure  evolution  protein stability  protein language model  CP: Molecular biology
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