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An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair
Affiliation:1. Duke Regeneration Center, Duke University, Durham, NC, USA;2. Department of Cell Biology, Duke University Medical School, Durham, NC, USA;3. Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA;4. Department of Biomedical Engineering, Duke University, Durham, NC, USA;5. Department of Surgery, Duke University School of Medicine, Durham, NC, USA;6. Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA;7. Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA;8. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel;9. Department of Medicine, Duke University Medical Center, Durham, NC, USA;10. Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC, USA;11. Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA;12. Department of Biological Chemistry and Pharmacology, Ohio State University, Columbus, OH, USA;13. Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA;14. Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA
Abstract:
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  • Keywords:gene therapy  tissue regeneration  enhancers  heart regeneration  cardiomyocyte proliferation  zebrafish  mouse  pig  YAP
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