首页 | 本学科首页   官方微博 | 高级检索  
     


METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
Affiliation:1. Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA;2. School of Pharmacy, China Medical University, Shenyang, Liaoning 110001, China;3. City of Hope Comprehensive Cancer Center and Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA 91010, USA;4. Department of Hematologic Malignancies Translational Science, City of Hope, Monrovia, CA 91016, USA;5. Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China;6. Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China;7. Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China;8. Department of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China;9. School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China;10. Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
Abstract:
><ol class=
  • Download : Download high-res image (188KB)
  • Download : Download full-size image
  • Keywords:METTL16  m6A modification  AML  leukemia stem cells  leukemia-initiating cells  LSCs/LICs  self-renewal  BCAA metabolism  BCAT1  BCAT2
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号