Porphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila melanogaster |
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| Authors: | Abdul Hai Nadeem A Kizilbash SyedaHuma H Zaidi Jamal Alruwaili |
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| Institution: | 1.Department of Biochemistry, Faculty of Medicine & Applied Medical Sciences, Northern Border University;2.Department of Chemistry, Faculty of Science, Northern Border University, P.O. Box 1321, Arar-91431, Saudi Arabia |
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| Abstract: | The cure for Alzheimer''s disease (AD) is still unknown. According to Cholinergic hypothesis, Alzheimer''s disease is caused by the
reduced synthesis of the neurotransmitter, Acetylcholine. Regional cerebral blood flow can be increased in patients with
Alzheimer''s disease by Acetylcholinesterase (AChE) inhibitors. In this regard, Tetraphenylporphinesulfonate (TPPS), 5,10,15,20-
Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl)
porphyrinatoIron(III) nitrosyl Chloride (FeNOTPPS) were investigated as candidate compounds for inhibition of
Acteylcholinesterase of Drosophila melanogaster (DmAChE) by use of Molecular Docking. The results show that FeNOTPPS forms
the most stable complex with DmAChE. |
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| Keywords: | Acetylcholinesterase Acetylcholinesterase inhibitors Cholinergic hypothesis Porphyrin derivatives Molecular Docking |
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