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Inter-Individual and Inter-Strain Variations in Zebrafish Locomotor Ontogeny |
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| Authors: | Merlin Lange Frederic Neuzeret Benoit Fabreges Cynthia Froc Sebastien Bedu Laure Bally-Cuif William H. J. Norton |
| Affiliation: | 1. Zebrafish Neurogenetics, Neurobiologie et Développement, Insitut de Neurobiologie Albert Fessard, Centre National de la Recherche Scientifique, Gif-sur-Yvette, Essonne, France.; 2. ViewPoint Life Sciences, Lissieu, Rhône, France.; 3. Département de Mathématiques, Université Paris-Sud 11, Orsay, Essonne, France.; 4. Department of Biology, University of Leicester, Leicester, Leicestershire, United Kingdom.; Institut Curie, France, |
| Abstract: | Zebrafish exhibit remarkable alterations in behaviour and morphology as they develop from early larval stages to mature adults. In this study we compare the locomotion parameters of six common zebrafish strains from two different laboratories to determine the stability and repeatability of these behaviours. Our results demonstrate large variability in locomotion and fast swim events between strains and between laboratories across time. These data highlight the necessity for careful, strain-specific controls when analysing locomotor phenotypes and open up the possibility of standardising the quantification of zebrafish behaviour at multiple life stages. |
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