Acid-degradable cationic dextran particles for the delivery of siRNA therapeutics |
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| Authors: | Cohen Jessica L Schubert Stephanie Wich Peter R Cui Lina Cohen Joel A Mynar Justin L Fréchet Jean M J |
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| Affiliation: | College of Chemistry, University of California, Berkeley, California 94720-1460, United States. |
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| Abstract: | We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity. This knockdown was comparable to that obtained using Lipofectamine, a commercially available transfection reagent generally limited to in vitro use due to its high toxicity. |
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