Center for Advanced Microstructures and Devices/Pennington Biomedical Research Center/6980 Jefferson Hwy, Baton Rouge, LA 70806, USA. ckumarl@lsu.edu
Abstract:
Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as glutaric acid (Glu) in between SPION and LHRH increases further receptor mediated intracellular uptake. LHRH-bound SPIONs with and without the spacer molecule were nontoxic.