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Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH-SPION into human breast cancer cells |
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| Authors: | Kumar Challa S S R Leuschner Carola Urbina Michelle Ozkaya Teyhida Hormes Josef |
| Institution: | Center for Advanced Microstructures and Devices/Pennington Biomedical Research Center/6980 Jefferson Hwy, Baton Rouge, LA 70806, USA. ckumarl@lsu.edu |
| Abstract: | Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as glutaric acid (Glu) in between SPION and LHRH increases further receptor mediated intracellular uptake. LHRH-bound SPIONs with and without the spacer molecule were nontoxic. |
| Keywords: | Glutaric acid luteinizing hormone releasing hormone superparamagnetic iron oxide nanoparticles MDA-MB-435S luc intracellular uptake |
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