Detection of G-C rich heterochromatin by 5-azacytidine in mammals |
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| Authors: | Evani Viegas-Péquignot Bernard Dutrillaux |
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| Affiliation: | (1) Institut de Progenèse, 15, rue de l'Ecole de Médecine, F-75006 Paris, France;(2) Departement de Protection, Service de Pathologie et de Protection Sanitaire, Commisariat à l'Energie Atomique, BP n0 6, F-92260 Fontenay aux Roses, France |
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| Abstract: | Summary A new effect of 5-ACR (5-azacytidine), observed in fibroblast or kidney cell cultures is described in the calf (Bos taurus) and in some selected primates (Cebus capucinus, Erythrocebus patas, and Cercopithecus cephus). This cytidine analogue, used at low doses during the last late S phase, prevents the condensation of R-band positive heterochromatin (G-C rich segments). Thus, 5-ACR treatment can be used as a simple method for the detection of G-C rich heterochromatin. |
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