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Partition function and base pairing probabilities of RNA heterodimers |
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| Authors: | Stephan H Bernhart Hakim Tafer Ulrike Mückstein Christoph Flamm Peter F Stadler Ivo L Hofacker |
| Institution: | 1. Theoretical Biochemistry Group, Institute for Theoretical Chemistry, University of Vienna, W?hringerstrasse 17, Vienna, Austria 2. Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, University of Leipzig, H?rtelstrasse 16–18, D-04170, Leipzig, Germany 3. The Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, New Mexico |
| Abstract: | BackgroundRNA has been recognized as a key player in cellular regulation in recent years. In many cases, non-coding RNAs exert their function by binding to other nucleic acids, as in the case of microRNAs and snoRNAs. The specificity of these interactions derives from the stability of inter-molecular base pairing. The accurate computational treatment of RNA-RNA binding therefore lies at the heart of target prediction algorithms. |
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