Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites |
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Authors: | Song Ju Yeon Jeong Haeyoung Yu Dong Su Fischbach Michael A Park Hong-Seog Kim Jae Jong Seo Jeong-Sun Jensen Susan E Oh Tae Kwang Lee Kye Joon Kim Jihyun F |
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Affiliation: | Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea. |
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Abstract: | Streptomyces clavuligerus is an important industrial strain that produces a number of antibiotics, including clavulanic acid and cephamycin C. A high-quality draft genome sequence of the S. clavuligerus NRRL 3585 strain was produced by employing a hybrid approach that involved Sanger sequencing, Roche/454 pyrosequencing, optical mapping, and partial finishing. Its genome, comprising four linear replicons, one chromosome, and four plasmids, carries numerous sets of genes involved in the biosynthesis of secondary metabolites, including a variety of antibiotics. |
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