Antiproliferative and apoptotic sesquiterpene lactones from Carpesium faberi |
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Authors: | Li Xu-Wen Weng Liang Gao Xue Zhao Yun Pang Fei Liu Jian-Hui Zhang Hong-Feng Hu Jin-Feng |
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Institution: | a Department of Natural Products for Chemical Genetic Research, Key Laboratory of Brain Functional Genomics, Ministry of Education & Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, No. 3663 Zhongshan Road N, Shanghai 200062, PR China b Institute of Biomedical Sciences, School of Life Science, East China Normal University, No. 3663 Zhongshan Road N, Shanghai 200062, PR China c Research Center of Medical Chemistry & Chemical Biology, Chongqing Technology and Business University, No. 19 Xuefu Ave., Nan’an District, Chongqing 400067, PR China |
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Abstract: | Four new (1-4) and 13 known (5-17) sesquiterpene lactones along with two known diterpenes (18, 19) were isolated from the whole plant of Carpesium faberi. The new structures were elucidated by means of spectroscopic techniques and some chemical transformations to be pseudoguaian-1α(H)-8α,12-olide-4β-O-β-d-glucopyranoside (1), 4β,10α-dihydroxy-5α(H)-1,11(13)-guaidien-8α,12-olide (2), 4β,10β-dihydroxy-5α(H)-1, 11(13)-guaidien-8β,12-olide (3), and (4S)-acetyloxyl-11(13)-carabren-8β,12-olide (4). All isolates were tested against MCF-7 human breast cancer cells using the MTT assay. Among them, the sesquiterpene lactones (except tomentosin 17) possessing an α-methylene-γ-lactone moiety were found to have in vitro antiproliferative activities, with IC50 values of 3.0-38.8 μg/mL. The effects of four selected sesquiterpene lactones (guaianolide 2, carabranolide 4, pseudoguaianolide 9, eudesmanolide 13) on the cell cycle were examined using flow cytometry (FCM). |
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Keywords: | Carpesium faberi Compositae Sesquiterpene lactones Antiproliferative |
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