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Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1 |
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| Authors: | Tynebor Robert M Chen Meng-Hsin Natarajan Swaminathan R O'Neill Edward A Thompson James E Fitzgerald Catherine E O'Keefe Stephen J Doherty James B |
| Institution: | a Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA b Department of Inflammation Research, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA |
| Abstract: | The development and synthesis of potent p38α MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38α selective pyridopyridazin-6-one series from the p38α/β dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail. |
| Keywords: | p38 inhibitors Selective Pyridopyridazin-6-one Rheumatoid arthritis |
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