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Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata |
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| Authors: | Dao Trong Tuan Nguyen Phi Hung Lee Hong Sik Kim Eunhee Park Junsoo Lim Seong Il Oh Won Keun |
| Institution: | a BK21 Project Team, College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Republic of Korea b Choong Ang Vaccine Laboratory, 59-3 Hwaam-dong, Yuseong-gu, Daejeon 305-348, Republic of Korea c Division of Biological Science and Technology, Yonsei University, Wonju 220-100, Republic of Korea d Traditional Food Research Group, Korea Food Research Institute, Sungnam 463-746, Republic of Korea |
| Abstract: | The emergence of highly pathogenic influenza A virus strains, such as the new H1N1 swine influenza (novel influenza), represents a serious threat to global human health. During our course of an anti-influenza screening program on natural products, one new licochalcone G (1) and seven known (2-8) chalcones were isolated as active principles from the acetone extract of Glycyrrhiza inflata. Compounds 3 and 6 without prenyl group showed strong inhibitory effects on various neuraminidases from influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, the efficacy of oseltamivir with the presence of compound 3 (5 μM) was increased against H274Y neuraminidase. This evidence of synergistic effect makes this inhibitor to have a potential possibility for control of pandemic infection by oseltamivir-resistant influenza virus. |
| Keywords: | Glycyrrhiza inflata Licochalcone G Influenza A Novel influenza H1N1 Neuraminidase inhibitors Oseltamivir resistance |
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