Hyperthermia-induced modulation of killing and mutation by UV and N-methyl-N'-nitro-N-nitrosoguanidine in V79 cells |
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| Authors: | S Banerjee G Bhaumik S B Bhattacharjee |
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| Institution: | Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Calcutta, India. |
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| Abstract: | Hyperthermic exposures of V79 cells did not affect the killing by UV light, whereas it enhanced MNNG-induced killing. Such hyperthermic exposure increased the mutation induction (resistance to 6-thioguanine) by both UV and MNNG. The timing of heat exposure, before or after the treatments, had no effect on the result in cases of cytotoxicity and mutagenesis. |
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