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Structure and Functions of Nuclear Matrix Associated Regions (S/MARs)
Authors:I. P. Chernov  S. B. Akopov  L. G. Nikolaev
Affiliation:(1) Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP, Moscow, 117997, Russia
Abstract:Modern concepts on the chromatin loop–domain organization and the role of the DNA regions specifically binding the nuclear matrix or nuclear scaffold (S/MARs) during its formation, maintenance, and regulation are discussed. Some S/MAR structural features, properties of binding the nuclear matrix, and probable mechanisms of their involvement in the gene regulation of activity are considered.
Keywords:chromatin  loop domains  MAR  nuclear matrix  nuclear scaffold  SAR
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