Structure and Functions of Nuclear Matrix Associated Regions (S/MARs) |
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Authors: | I. P. Chernov S. B. Akopov L. G. Nikolaev |
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Affiliation: | (1) Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP, Moscow, 117997, Russia |
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Abstract: | Modern concepts on the chromatin loop–domain organization and the role of the DNA regions specifically binding the nuclear matrix or nuclear scaffold (S/MARs) during its formation, maintenance, and regulation are discussed. Some S/MAR structural features, properties of binding the nuclear matrix, and probable mechanisms of their involvement in the gene regulation of activity are considered. |
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Keywords: | chromatin loop domains MAR nuclear matrix nuclear scaffold SAR |
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