Regulation of glutamate synthase from by Glutamine |
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Authors: | Kathryn L Desphande Jon R Katze James F Kane |
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Institution: | Department of Microbiology and Immunology University of Tennessee Center for Health Sciences Memphis, Tennessee 38163 USA |
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Abstract: | Glutamate synthase, an important enzyme in the assimilation of ammonia, was measured in cultures of grown with different nitrogen sources. An attempt was made to correlate the specific activity to the intracellular levels of five metabolites of glutamate metabolism: aspartate, glutamate, glutamine, alanine and . An inverse relationship was found between the activity of glutamate synthase and the pool level of glutamine. We propose that the intracellular concentration of glutamine is an important element in controlling the level of glutamate synthase. |
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