Linkage of the HMP pathway to ATP generation by the proline cycle |
| |
Authors: | James M Phang Sylvia J Downing Grace Chao Yeh |
| |
Institution: | Endocrine Section, Metabolism Branch, National Cancer Institute National Institutes of Health, Bethesda, Maryland 20205 USA |
| |
Abstract: | The reactions catalyzed by proline oxidase and pyrroline-5-carboxylate reductase form a catalytic cycle linking the hexose-monophosphate pentose (HMP) pathway to mitochondrial ATP generation. The cycling of proline and pyrroline-5-carboxylate couples glucose oxidation to ATP generation by a mechanism independent of the Embden-Meyerhof pathway and the tricarboxylic acid cycle. |
| |
Keywords: | To whom reprint requests should be sent |
本文献已被 ScienceDirect 等数据库收录! |