Linkage of the HMP pathway to ATP generation by the proline cycle |
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| Authors: | James M Phang Sylvia J Downing Grace Chao Yeh |
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| Institution: | Endocrine Section, Metabolism Branch, National Cancer Institute National Institutes of Health, Bethesda, Maryland 20205 USA |
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| Abstract: | The reactions catalyzed by proline oxidase and pyrroline-5-carboxylate reductase form a catalytic cycle linking the hexose-monophosphate pentose (HMP) pathway to mitochondrial ATP generation. The cycling of proline and pyrroline-5-carboxylate couples glucose oxidation to ATP generation by a mechanism independent of the Embden-Meyerhof pathway and the tricarboxylic acid cycle. |
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| Keywords: | To whom reprint requests should be sent |
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