The inhibitory effect of polymeric carboxylic amino-acids and urine on calcium oxalate crystallization |
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| Authors: | Nissim Garti Francoise Tibika Sara Sarig Shaul Perlberg |
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| Institution: | 1. Casali Institute of Applied Chemistry, School of Applied Science and Technology, Israel;7. Department of Urology, Hadassah-Medical School Israel |
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| Abstract: | A new method has been established to follow the inhibitory effect of some polymeric-dicarboxylic-amino-acids and other poly-anionic derivatives. The technique is based on using calcium specific electrode to measure continuously free calcium ion activity in solution to assess the formation of calcium oxalate precipitate.The retardation effect of Poly-L-glutamic and aspartic acids has been established in 5–100 ppm range and compared to other monomeric and polymeric compounds with inactivated functional groups. The retardation effect is in agreement with previous reports on inhibition effect on crystal growth rate of seed crystals, with the same retardants.The inhibitory effect was also determined with normal urine and compared to pathological urine. |
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