Induction of testosterone 16β-hydroxylase in rat liver microsomes by phenobarbital pretreatment |
| |
| Authors: | Yutaka Nakamura Seiko Ueda |
| |
| Affiliation: | Shionogi Research Laboratory, Shionogi & Co., Ltd., Fukushima-ku, Osaka, 553, Japan |
| |
| Abstract: | Oxidation products of testosterone in control rat liver microsomes were 16α-, 2α-, 6β-, 7α-hydroxytestosterone and 4-androstene-3,17-dione, but no 2β-hydroxytestosterone was detected. Increased testosterone 16β-hydroxylase activity and 4-androstene-3,17-dione production were found upon incubation of testosterone with phenobarbital-pretreated rat liver microsomes. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
