A role for cytidine monophosphate in the regulation of the glycerophospholipid composition of surfactant in developing lung |
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| Authors: | J.Gerald Quirk John E. Bleasdale Paul C. MacDonald John M. Johnston |
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| Affiliation: | 1. The Cecil H. and Ida Green Center for Reproductive Biology Sciences The University of Texas Southwestern Medical School 5323 Harry Hines Boulevard Dallas, Texas 75235 USA;2. Department of Biochemistry The University of Texas Southwestern Medical School 5323 Harry Hines Boulevard Dallas, Texas 75235 USA;3. Department of Obstetrics-Gynecology The University of Texas Southwestern Medical School 5323 Harry Hines Boulevard Dallas, Texas 75235 USA |
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| Abstract: | The concentration of cytidine monophosphate (CMP) in lung tissue was found to increase during rabbit lung development from 12 nmol/g of tissue on day 23 of gestation to 52 nmol/g in the adult. The concentrations of cytidine triphosphate in lung tissue decreased from 113 nmol/g of tissue on day 23 to 63 nmol/g of tissue in the adult. The concentration of CDP-choline increased from 14.9 nmol/g at day 21 of gestation to 38.4 at day 26 and decreased subsequently in the newborn (6.5 nmol/g) and adult (9.7 nmol/g). The increase in the concentration of CMP in lung appeared to be organ and nucleotide specific since there was no increase in the concentration of CMP in liver tissue, and the concentration of AMP in the lung tissue did not increase with development. A function for CMP in regulating the availability of CDP-diacylglycerol is proposed to account for the changes in the glycerophospholipid composition of lung surfactant which occur during development. |
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| Keywords: | PAPase phosphatidate phosphohydrolase (E.C. 3.1.3.4.) |
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