Tissue specificity of mitochondrial monooxygenase system for aflatoxin B1 activation |
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| Authors: | Banavadi G. Niranjan Narayan G. Avadhani |
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| Affiliation: | The Laboratories of Biochemistry, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA |
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| Abstract: | Rat liver mitoplasts free of detectable microsomal contamination can activate significant amounts of aflatoxin B1 (AFB1) into electrophilic reactive forms. The activated carcinogen binds to mitochondrial macromolecules and inhibits mitochondrial RNA and protein biosynthesis. The mitochondrial monooxygenase oxygenase system for AFB1 activation is restricted to liver and kidney as tested by enzyme assays and effects on mitochondrial RNA and protein synthesis. |
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