Calmodulin modulates phospholipid methylation in Dictyostelium discoideum

In the presence of (³H-methyl)-S-adenosyl-L-methionine $\text{Di}\text{ctyostelium discoideum}$ cell homogenates incorporate (³H-methyl) groups into mono- and dimethyl-phosphatidylethanolamine and phosphatidylcholine. The addition of bovine brain calmodulin enhances lipid transmethylation and an antiserum against rat brain calmodulin inhibits the reaction. EGTA and chlorpromazine, an inhibitor of calmodulin action, inhibit phospholipid methylation. Based on these results we propose that this reaction is modulated by calmodulin.