Desmutagenic actions of ascorbic acid and cysteine on a new pyrole mutagen formed by the reaction between food additives; Sorbic acid and sodium nitrite |
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| Authors: | Toshihiko Osawa Harue Ishibashi Mitsuo Namiki Tsuneo Kada |
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| Affiliation: | 1. Department of Food Science & Technology, Nagoya University, Chikusa, Nagoya, 464, Japan |
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| Abstract: | Mutagenicity of 1,4-dinitro-2-methyl pyrrole, a new mutagen isolated from the reaction mixture of sorbic acid and sodium nitrite, was found to be destroyed by treatment with ascorbic acid or cysteine. Chemical studies revealed that the loss of mutagenicity was due to reduction from the C-nitro to C-amino group. |
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| Keywords: | 1,4-dinitro-2-methyl pyrrole DNMP 1-nitro-2-methyl-4-amino pyrrole NMAP 5-nitro-2-furaldehyde semicarbazone, nitrofurazone, 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide AF-2 high pressure liquid chromatography HPLC ultra violet UV infrared IR nuclear magnetic resonance n.m.r |
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