Synthesis of a fluorescent boronic acid which reversibly binds to cell walls and a diboronic acid which agglutinates erythrocytes |
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Authors: | Thomas J. Burnett Henry C. Peebles James H. Hageman |
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Affiliation: | Department of Chemistry, New Mexico State University Las Cruces, New Mexico 88003 USA |
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Abstract: | N-(5-dimethylamino-1-napthalene sulfonyl)-3-aminobenzene boronic acid (Dns-PBA) and N,N′--3(dihydroxylborylbenzene)adipamide (Bis-PBA) were synthesized. The former is found to reversibly associate with , apparently through boronate diester linkages with carbohydrates on the cell surface. The latter displays the lectin-like property of agglutinating red blood cells. |
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