Adriamycin treatment increases 3-hydroxy-3-methylglutaryl CoA reductase and isoprene biosynthesis in the rat liver |
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Authors: | ASatish Menon T Ramasarma |
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Institution: | Department of Biochemistry Indian Institute of Science Bangalore 560012, India |
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Abstract: | Treatment of rats with Adriamycin caused an increase in the incorporation into hepatic cholesterol of 1-14C] acetate, but not of 2-14C] mevalonate. The step affected was found to be 3-hydroxy-3-methylglutaryl CoA reductase whose activity in the liver microsomes increased in Adriamycin-treated animals, but was inhibited when the drug was added in the assay medium. Also, the concentration of ubiquinone in the liver and of cholesterol in the plasma increased. |
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