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Effects of glucagon and Na+ on the control of extramitochondrial free Ca2+ concentration by mitochondria from liver and heart |
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| Authors: | M.D. Brand C. De Selincourt |
| Affiliation: | Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, U.K. |
| Abstract: | Rat liver mitochondria maintain the extramitochondrial free Ca2+ concentration at pCa2+ of about 6.15. Glucagon pre-treatment of the rats does not alter this value. Rat heart mitochondria maintain free Ca2+ at a pCa2+ value of about 6.7, addition of 5mM Na+ changes this to a value of about 5.85. |
| Keywords: | EGTA ethyleneglycolbis (aminoethyl) tetraacetate NTA nitrilotriacetate TES N-Tris-(hydroxymethyl)-methyl-2-amino-ethanesulphonic acid |
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