Purification of a serum DNA binding protein (64DP) with a molecular weight of 64,000 and its diagnostic significance in malignant diseases |
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| Authors: | Tsunehiko Katsunuma Michio Tsuda Takashi Kusumi Tomoichi Ohkubo Toshio Mitomi Hisao Nakasaki Tomoo Tajima Seihichi Yokoyama Hiroshi Kamiguchi Kazuo Kobayashi Hirotaka Shinoda |
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| Institution: | 1. Department of Biochemistry, School of Medicine, Tokai University, Bohseidai, Isehar, 259-11, Japan;2. Department of Surgery, School of Medicine, Tokai University, Bohseidai, Isehara, 259-11, Japan;3. Biochemistry Division of Interdepartmental Laboratory, School of Medicine, Tokai University, Bohseidai, Isehara, 259-11, Japan;4. Department of Obstetrics and Gynecology, School of Medicine, Tokai University, Bohseidai, Isehara, 259-11, Japan;5. Research Institute, Kyorin Pharmaceutical Co., LTD., Tokyo, Japan. |
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| Abstract: | A DNA binding protein with a molecular weight of 64,000(64DP) has been purified to homogeneity from human serum, and its quantitative assay has been developed. The average level of serum 64DP in 30 normal controls was 41.4 μg/ml, whereas it was 175 μg/ml in 87 patients with untreated malignant disease. Furthermore it was found to be elevated in all tested patients, 8 cases, with carcinoma in early stages. Serum 64DP has been found to be different from C3DP, CEA# or α-FP#, and it appears that this protein might prove to be a useful tumor marker in malignant diseases. |
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