Effect of imipramine hydrochloride on the activity of gamma-aminobutyric acid transaminase in regions of the rat brain |
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Authors: | Madhavi Ratnam Prakash Najma Zaheer Baquer |
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Institution: | School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India |
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Abstract: | The effect of intraperitoneal injection of imipramine hydrochloride on the activity of gamma-aminobutyric acid transaminase was determined in three regions of the rat brain.The cerebral hemispheres did not show a significant change in the activity of gamma-aminobutyric acid transaminase. Cerebellum and brain stem, both, however, showed a very significant decrease in the activity of the enzyme at 15 and 30 minutes after drug administration. At 90 minutes after drug administration, the activity of gamma-aminobutyric acid transaminase had returned to nearly control values. |
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