Dictamnine,an alkaloid which crosslinks DNA in the presence of ultraviolet light |
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| Authors: | G.H.N. Towers F.W. Whitehead Z.A. Abramowski J.C. Mitchell |
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| Affiliation: | 1. Department of Botany, University of British Columbia, Vancouver, B.C., Canada V6T 1W5;7. Division of Dermatology University of British Columbia, Vancouver, B.C., Canada V6T 1W5 |
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| Abstract: | In the presence of ultraviolet light, the furoquinoline alkaloid, dictamnine, caused calf thymus DNA to become easily renaturable. The effect was less pronounced than for the furocoumarin, 8-methoxypsoralen. Ease of renaturation is evidence of the formation of interstrand crosslinks in DNA. The mechanism of crosslink formation by this alkaloid may be like that of 8-methoxypsoralen. |
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