Biphasic increase in ornithine decarboxylase and its relationship with thymidine kinase and DNA synthesis in liver: Effects of dietary protein and amino acid mixture |
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Authors: | Ishtiaq Mahmud Mineko Asanagi Yoshiaki Miura |
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Institution: | Department of Biochemistry, Chiba University School of Medicine, Chiba 280, Japan |
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Abstract: | In rats, feeding protein free diet for 4 days followed by starvation and then high protein diet induced a biphasic ornithine decarboxylase (EC 4.1.1.17) activity, prolonged thymidine kinase (EC 2.7.1.21) activity and DNA synthesis. In contrast feeding a diet containing casein-equivalent amino acid mixture induced a monophasic ornithine decarboxylase activity, short-lived thymidine kinase activity and DNA synthesis. To maintain prolonged thymidine kinase activity and DNA synthesis high protein diet must be given in the early part of the prereplicative period. |
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Keywords: | ODC ornithine decarboxylase t-RNA transfer RNA r-RNA ribosomal RNA Tdr kinase thymidine kinase |
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