Comparison of coenzyme F<sub>420</sub> from <span class="math"><math><mtext>Methanobacterium bryantii</mtext></math></span> with 7- and 8-hydroxy-10-methyl-5-deazaisoalloxazine期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Comparison of coenzyme F₄₂₀ from $Methanobacterium bryantii$ with 7- and 8-hydroxy-10-methyl-5-deazaisoalloxazine

Authors:	Arjan Pol Chris van der Drift Godfried D Vogels Theo JHM Cuppen Wim H Laarhoven

Institution:	1. Department of Microbiology, Faculty of Science, University of Nijmegen, 6525 ED Nijmegen, The Netherlands;2. Department of Organic Chemistry, Faculty of Science, University of Nijmegen, 6525 ED Nijmegen, The Netherlands

Abstract:	Syntheses of 7-hydroxy-10-methyl-5-deazaisoalloxazine (7-HMDI) and 8-hydroxy-10-methyl-5-deazaisoalloxazine (8-HMDI) are described. The physicochemical and biological properties of 8-HMDI, in contrast to those of 7-HMDI, are very analogous to those of F₄₂₀, a coenzyme found in methanogenic bacteria.

Keywords:	AUR auromomycin MCR macromomycin NCS neocarzinostatin MIa the methanol-insoluble fraction of AUR MIn the methanol-insoluble fraction of NCS MSa the methanol-soluble fraction of AUR MSn the methanol-soluble fraction of NCS
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