Primary induction of metallothionein by dexamethasone in cultured rat hepatocytes |
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| Authors: | Michael Karin Harvey R. Herschman David Weinstein |
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| Affiliation: | 1. Molecular Biology Institute, School of Medicine, UCLA, Los Angeles CA 90024 USA;2. Dept. of Biological Chemistry, School of Medicine, UCLA, Los Angeles CA 90024 USA;3. Laboratory of Nuclear Medicine and Radiation Biology, School of Medicine, UCLA, Los Angeles CA 90024 USA;4. Division of Metabolic Disease, Dept. of Medicine; M-013D University of California, San Diego, La Jolla CA 92093 USA |
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| Abstract: | Dexamethasone or Zn++ increase the rate of synthesis of the metal-binding protein metallothionein in hepatocyte cultures. Dexamethasone induction of the capacity to synthesize metallothionein is not blocked by cycloheximide. In contrast, the dexamethasone stimulated increase in Zn++ uptake is inhibited by cycloheximide. Like Zn++, dexamethasone is a “primary inducer” of metallothionein. The glucocorticoid induction of metallothionein in primary cultures of rat hepatocytes is not mediated through elevation of Zn++ uptake. |
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