The inhibition of cholesterol biosynthesis in MRC-5 fibroblasts in culture by cholesta-5,7,9-trien-3β-ol |
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| Authors: | Valerie Shakespeare David C. Wilton |
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| Affiliation: | Department of Biochemistry, University of Southampton, Southampton, Hants, S09 3TU, England. |
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| Abstract: | Cholesta-5,7,9-trienol-3β-ol is a potent inhibitor of cholesterol biosynthesis and the enzyme 3-hydroxy-3-methyl-glutaryl CoA reductase in MRC-5 fibroblasts in culture. A similar type of inhibition is not exhibited by cholesta-5,7-dien-3β-ol, cholesta-7,9-dien-3β-ol or cholesterol. |
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