Transformation of alpha-santonin via two independent pathways by Pseudomonas strain S ATCC 43388 |
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| Authors: | D. Colaco I. Furtado U. P. Naik S. Mavinkurve S. K. Paknikar |
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| Affiliation: | †Departments of Microbiology, Goa University, Taleigao Plateau, Goa, India 403 202;§Departments of Chemistry, Goa University, Taleigao Plateau, Goa, India 403 202;‡Department of Biochemistry, State University of Brooklyn, Brooklyn, NY, USA |
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| Abstract: | Pseudomonas strain S (ATCC 43388) transforms alpha-santonin in the presence of dicyclohexylcarbodiimide (DCCD) to 1,2-dihydrosantonin (DHS) and two more products, D1 and D2. D2 was identified as 4,5-dihydroxysantonin (DHXS). Cells incubated with semicarbazide (SC) formed DHXS but not DHS. Simultaneous formation of DHS and DHXS is indicative of the presence of two distinct pathways of alpha-santonin biotransformation. |
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