The regulation of cell growth: II. Some characteristics of a fetal calf serum factor (FF2) stimulating ornithine decarboxylase in mouse liver |
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| Authors: | Colin GD Morley |
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| Institution: | Department of Obstetrics and Gynecology, Biochemistry and Laboratory Animal Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284, U.S.A. |
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| Abstract: | A heat stable, non-dialysable fetal calf serum factor (FF2), capable of stimulating ornithine decarboxylase in mouse liver, kidney and spleen, has been detected in fetal calf serum and commercial preparations of 81% pure fetuin.The factor has a molecular weight of approx. 17 500, contains sulfhydryl groups necessary for its activity, and is protease resistant.Stimulation of hepatic ornithine decarboxylase by the fetal calf serum factor is dose and time dependent and is blocked by both cycloheximide and by actinomycin D, if the latter is administered within 1 h of the factor. Theophylline enhances the effect of the fetal calf serum factor on ornithine decarboxylase in the liver and the factor stimulate ornithine decarboxylase in hypophysectomized and adrenalectomized rats. |
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| Keywords: | fetal carl serum factor |
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