Zinc modulates copper coordination mode in prion protein octa-repeat subdomains |
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| Authors: | Francesco Stellato Ann Spevacek Olivier Proux Velia Minicozzi Glenn Millhauser Silvia Morante |
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| Institution: | 1.Dipartimento di Fisica,Università di Roma ‘Tor Vergata’,Rome,Italy;2.Centre for Free-Electron Laser Science, DESY,Hamburg,Germany;3.Department of Chemistry and Biochemistry,University of California,Santa Cruz,USA;4.Observatoire des Sciences de l’Univers de Grenoble, CNRS and Université Joseph Fourier,Grenoble Cedex 9,France |
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| Abstract: | In this work we present and analyse XAS measurements carried out on various portions of Prion-protein tetra-octa-repeat peptides
in complexes with Cu(II) ions, both in the presence and in the absence of Zn(II). Because of the ability of the XAS technique
to provide detailed local structural information, we are able to demonstrate that Zn acts by directly interacting with the
peptide, in this way competing with Cu for binding with histidine. This finding suggests that metal binding competition can
be important in the more general context of metal homeostasis. |
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