| Abstract: | The antiaggregatory effects of 6-oxo-PGE1 were evaluated in the rat using a minimally invasive technique involving 111-Indium labelling of platelets. The antiaggragatory effects on adenosine diphosphate-induced aggregation were compared with those of prostacyclin (PGI2) and prostalandin E1 (PGE1) following slow infusions and bolus injections. The rank order of antiaggregatory potency was PGI2 > 6-oxo-PGE1 > PGE1 while the rank order of duration of antiaggregatory effects was PGE1 > 6-oxo-PGE1 > PGI2. The kinetics of the antiaggregatory effects of these prostaglandins suggests that such action are not mediated by direct effects on platelets, but through a secondary mechanism. |
