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The study of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel and their effects on microspheres preparation and drug release |
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| Authors: | Fwu-Long Mi Chih-Yang Kuan Shin-Shing Shyu Sung-Tao Lee Shon-Foun Chang |
| Institution: | a Division of Chemistry, Department of Mathematics, Physics and Chemistry, Chinese Naval Academy, Kaoshing, Taiwan b Polymer Division, Department of Chemical Engineering, National Central University, Chung-Li, Taiwan c SEM Laboratory, National Science Council, Taipei, Taiwan |
| Abstract: | The effects of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel on microspheres preparation or drug release were studied. The rate of gelation is zero order corresponding to the chitosan concentration but non-zero order corresponding to the glutaraldehyde concentration. It was suggested that the cross-linking reaction was mainly dominated by the concentration of small molecule reactant, glutaraldehyde. The relaxation of an entangled polymer chain in a gel network as a result of the swelling of cross-linked chitosan hydrogel was investigated by the stress–strain determination. The higher the cross-linking density of chitosan hydrogel, the lower the swelling ability of chitosan hydrogel due to the slower relaxation rate of polymer chain, which then results in the decreased drug-release rate. |
| Keywords: | Chitosan Glutaraldehyde Gelation kinetics Chain-relaxation Microsphere Drug-release |
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