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An antecedent of the MHC-linked genomic region in amphioxus
Authors:L?Filipe?C?Castro  Rebecca?F?Furlong  Email author" target="_blank">Peter?W?H?HollandEmail author
Institution:(1) Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK;(2) Department of Biology, University College London, Gower Street, London, WC1E 6BT, UK
Abstract:The MHC genes on human chromosome 6 are located within one of the best-characterised paralogy regions of the human genome. Numerous genes mapping around this location, 6p21, have paralogues at one, two or three other chromosomal locations on HSA 1, 9 and 19. The similarity between these four chromosomal regions suggests the linkages may have adaptive significance, and/or they may be echoes of segmental or genome duplication in human ancestry. Here, we show that six amphioxus cosmids, containing genes orthologous to those from the human MHC-linked paralogy regions, map to a single amphioxus chromosome. The composition of the MHC-linked genomic region, therefore, pre-dates vertebrate origins.
Keywords:Genome evolution  Paralogy  FISH
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