Variations in levels of cAMP, DNA and RNA in Streptomyces alboniger under conditions of aerial mycelium formation and repression

Abstract The relationship between endogenous levels of cyclic adenosine 3',5'-monophosphate (cAMP) and the formation of aerial mycelia was investigated in Streptomyces alboniger under conditions of aerial mycelium formation and repression. The relationship between cellular levels of DNA and RNA and aerial mycelium formation was also investigated. In contrast to cellular differentiation in other Streptomyces , neither variations in cAMP, DNA or RNA levels were found to be associated with the development of aerial mycelia in S. alboniger . The regulation of adenylate cyclase in S. alboniger , however, was found to differ from that of Escherichia coli and related organisms in that glucose raised, rather than lowered, endogenous cAMP levels.