An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue |
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| Authors: | Christine L Le Maitre Pauline Baird Anthony J Freemont Judith A Hoyland |
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| Institution: | (1) Biomedical Research Centre, Biosciences, Faculty of Health and Wellbeing, Sheffield Hallam University, City Campus, Owen Building, Howard Street, Sheffield, S1 1WB, UK;(2) Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK |
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| Abstract: | Introduction The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain,
and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed
as potential treatments for IVD degeneration. One such therapy under investigation by a number of groups worldwide is the
use of autologous mesenchymal stem cells (MSCs) to aid in the regeneration of the IVD extracellular matrix. To date, however,
the optimum method of application of these cells for regeneration strategies for the IVD is unclear, and few studies have
investigated the direct injection of MSCs alone into IVD tissues. In the present article, we investigated the survival and
phenotype of human MSCs, sourced from aged individuals, following injection into nucleus pulposus (NP) tissue explant cultures. |
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