Synthesis of the Glc3Man N-glycan tetrasaccharide by iterative allyl IAD |
| |
| Authors: | Attolino Emanuele Cumpstey Ian Fairbanks Antony J |
| |
| Institution: | Chemistry Research Laboratory, Oxford University, Mansfield Road, Oxford OX1 3TA, UK. |
| |
| Abstract: | The synthesis of the tetrasaccharide alpha-D-Glcp-(1-->2)-alpha-D-Glcp-(1-->3)-alpha-D-Glcp-(1-->3)-alpha-D-Manp-OMe, corresponding to the terminal tetrasaccharide portion of the glucose terminated arm of the N-glycan tetradecasaccharide, was achieved with complete stereocontrol by the use of iterative allyl protecting group mediated intramolecular aglycon delivery (allyl IAD) demonstrating the utility of intramolecular glycosylation for the stereocontrolled construction of multiple glycosidic linkages during the synthesis of an oligosaccharide. |
| |
| Keywords: | Carbohydrates Intramolecular Glycosylation Allyl Intramolecular aglycon delivery Thioglycosides Glycoproteins |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
