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The influence of low arylsulfatase A activity on neuropsychiatric morbidity: a large-scale screening in patients |
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| Authors: | P. Propping W. Friedl M. Huschka K. -H. Schlör F. Reimer M. Lee-Vaupel E. Conzelmann K. Sandhoff |
| Affiliation: | (1) Institut für Humangenetik der Universität, Wilhelmstrasse 31, D-5300 Bonn 1, Federal Republic of Germany;(2) Institut für Anthropologie und Humangenetik der Universität, Im Neuenheimer Feld 328, D-6900 Heidelberg, Federal Republic of Germany;(3) Landeskrankenhaus Weinsberg, D-7102 Weinsberg, Federal Republic of Germany;(4) Institut für Organische Chemie und Biochemie der Universität, Gerhard-Domagk-Strasse 1, D-5300 Bonn 1, Federal Republic of Germany |
| Abstract: | Summary A total of 1728 patients consecutively admitted to a neuropsychiatric hospital and 379 chronically ill inpatients were examined for activity of arylsulphatase A (ASA) in leucocytes. A further 519 healthy individuals served as controls. We did not find evidence for the involvement of low ASA activity in chronic patients. The consecutive admissions showed a slight preponderance in the lower ASA activity classes. This activity range covers persons heterozygous for ASA deficiency alleles. The data are compatible with the hypothesis that carriers of low ASA activity alleles are at a slightly higher risk for neuropsychiatric disorders.Dedicated to Professor Dr. E. Zerbin-Rüdin on the occasion of her 65th birthday |
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