Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity |
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Authors: | Röhrich Christian Rene Ngwa Che Julius Wiesner Jochen Schmidtberg Henrike Degenkolb Thomas Kollewe Christian Fischer Rainer Pradel Gabriele Vilcinskas Andreas |
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Institution: | Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Giessen, Germany. |
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Abstract: | The harlequin ladybird beetle Harmonia axyridis has been introduced in many countries as a biological control agent, but has become an invasive species threatening the biodiversity of native ladybirds. Its invasive success has been attributed to its vigorous resistance against diverse pathogens. This study demonstrates that harmonine ((17R,9Z)-1,17-diaminooctadec-9-ene), which is present in H. axyridis haemolymph, displays broad-spectrum antimicrobial activity that includes human pathogens. Antibacterial activity is most pronounced against fast-growing mycobacteria and Mycobacterium tuberculosis, and the growth of both chloroquine-sensitive and -resistant Plasmodium falciparum strains is inhibited. Harmonine displays gametocytocidal activity, and inhibits the exflagellation of microgametocytes and zygote formation. In an Anopheles stephensi mosquito feeding model, harmonine displays transmission-blocking activity. |
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Keywords: | Harmonia axyridis insect immunity harmonine antimicrobial activity |
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