Flavonoids: structural requirements for antiproliferative activity on breast cancer cells |
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| Authors: | Christelle Pouget, Fabienne Lauthier, Alain Simon, Catherine Fagnere, Jean-Philippe Basly, Christiane Delage,Albert-Jos Chulia |
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| Affiliation: | UPRES EA 1085, ‘Biomolécules et cibles cellulaires tumorales’, Faculté de Pharmacie, 2 rue du Docteur Marcland, 87025, Limoges Cedex, France |
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| Abstract: | Several classes of flavonoids (flavones, flavanones, 2′-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast cancer cells. Structure–activity relationships of these compounds were discussed. 2′-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas flavones and flavan-4-ols appeared to be weak inhibitory agents except 7,8-dihydroxyflavone. |
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