cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20) |
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Authors: | Mitsui S Okui A Kominami K Uemura H Yamaguchi N |
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Institution: | Department of Cell BIology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Japan. |
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Abstract: | Two splicing variants of mouse hippostasin/TLSP (PRSS20) were identified and termed brain-type and prostate-type, respectively. Mouse hippostasin/TLSP showed 76.8% identity to the human homologue. Transient expression showed that both translational products were secreted into the conditioned medium. Mouse hippostasin/TLSP was expressed preferentially in the fetal brain and the prostate, but not in the neonatal brain. The brain expressed only brain-type hippostasin/TLSP, while the prostate expressed both types. |
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