The involvement of serotonin receptors in suanzaorentang-induced sleep alteration |
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Authors: | Pei-Lu Yi Chun-Pang Lin Chon-Haw Tsai Jaung-Geng Lin Fang-Chia Chang |
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Institution: | (1) Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan;(2) Shih-Hwa Chinese Medicine Clinic, Tainan, Taiwan;(3) Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan;(4) Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan;(5) Department of Veterinary Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan, ROC |
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Abstract: | Summary Sedative-hypnotic medications, including benzodiazepines and non-benzodiazepines, are usually prescribed for the insomniac
patients; however, the addiction, dependence and adverse effects of those medications have drawn much attention. In contrast,
suanzaorentang, a traditional Chinese herb remedy, has been efficiently used for insomnia relief in China, although its mechanism
remains unclear. This study was designed to further elucidate the underlying mechanism of suanzaorentang on sleep regulation.
One ingredient of suanzaorentang, zizyphi spinosi semen, exhibits binding affinity for serotonin (5-hydroxytryptamine, 5-HT)
receptors, 5-HT1A and 5-HT2, and for GABA receptors. Our previous results have implicated that GABAA receptors, but not GABAB, mediate suanzaorentang-induced sleep alteration. In current study we further elucidated the involvement of serotonin. We
found that high dose of suanzaorentang (4 g/kg/2 ml) significantly increased non-rapid eye movement sleep (NREMS) when comparing
to that obtained after administering starch placebo, although placebo at dose of 4 g/kg also enhanced NREMS comparing with
that obtained from baseline recording. Rapid eye movement sleep (REMS) was not altered. Administration of either 5-HT1A antagonist (NAN-190), 5-HT2 antagonist (ketanserin) or 5-HT3 antagonist (3-(4-Allylpiperazin-1-yl)-2-quinoxalinecarbonitrile) blocked suanzaorentang-induced NREMS increase. These results
implicate the hypnotic effect of suanzaorentang and its effects may be mediated through serotonergic activation, in addition
to GABAergic system. |
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Keywords: | suanzaorentang non-rapid eye movement sleep (NREMS) rapid eye movement sleep (REMS) serotonin |
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