Generation of HIV latency in humanized BLT mice |
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Authors: | Denton Paul W Olesen Rikke Choudhary Shailesh K Archin Nancy M Wahl Angela Swanson Michael D Chateau Morgan Nochi Tomonori Krisko John F Spagnuolo Rae Ann Margolis David M Garcia J Victor |
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Affiliation: | Division of Infectious Diseases, Department of Internal Medicine, Center for AIDS Research, University of North Carolina, Chapel Hill, North Carolina, USA. |
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Abstract: | Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (ART)-treated humanized BLT mice harbor latently infected resting human CD4+ T cells that can be induced ex vivo to produce HIV. We observed that the levels of infected resting human CD4+ T cells present in BLT mice are within the range of those observed circulating in patients undergoing suppressive ART. These results demonstrate the potential of humanized BLT mice as an attractive model for testing the in vivo efficacy of novel HIV eradication strategies. |
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